新規のビタミンB12結合様式を持つジオールデヒドラターゼの立体構造と補酵素活性化機構
2000 年 42 巻 4 号 p. 354-360
詳細
2000 年 42 巻 4 号 p. 354-360
Diol dehydratase is an adenosylcobalamin-dependant enzyme that catalyzes conversion from 1, 2-diol compounds to corresponding aldehydes. The crystal structure of the enzyme shows that B12 compounds are incorporated with the DBI-on mode. The enzyme has a potassium ion at the active site, where the substrate coordinates to it. The structure of the enzyme complexed with adeninylpentylcobalamin reveals the activation mechanism of adenosylcobalamin.
