グルタミルtRNA合成酵素・tRNAGlu複合体の結晶構造が示すアンチコドン認識のメカニズム
2002 年 44 巻 6 号 p. 375-379
詳細
2002 年 44 巻 6 号 p. 375-379
Strict recognition of both tRNA and amino acid by aminoacyl-tRNA synthetase is essential for the faithful protein biosynthesis. We have determined a crystal structure of Thermus thermophilus glutamyl-tRNA synthetase (GluRS) in complex with its cognate tRNAGlu. The structure provided the molecular basis of strict tRNA recognition by GluRS and insights into evolution of the enzyme anticodon specificity.
