酵素タンパク質反応の分子機構に関する結晶学的研究
―プロテインホスファターゼ1―カリクリンA複合体―
2003 年 45 巻 3 号 p. 178-184
詳細
2003 年 45 巻 3 号 p. 178-184
The crystal structure of catalytic subunit of the protein phosphatase 1 (PP1), PP1γ, in complex with a marine toxin, calyculin A, was determined at 2.0 Å resolution. Calyculin A is located in two of the three major grooves, namely, in the hydrophobic groove and the acidic groove on the molecular surface. This is the first case that the inhibitor does not adopt a pseudocyclic conformation but an extended one in order to form a complex with the protein.
