日本結晶学会誌
Online ISSN : 1884-5576
Print ISSN : 0369-4585
ISSN-L : 0369-4585
糖鎖認識ユビキチンリガーゼの立体構造から明らかになった蛋白質分解のための糖鎖の役割
水島 恒裕
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ジャーナル フリー

2005 年 47 巻 3 号 p. 197-203

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SCFFbsl is a ubiquitin-ligase that plays a role in the endoplasmic reticulum-associated degradation pathway. Fbsl/Fbx2, a member of the F-box proteins, recognizes high-mannose oligosaccharides. The structure of the sugar-binding domain-chitobiose complex includes hydrogen bonds between Fbs1 and chitobiose and insertion of the methyl-group of chitobiose into a small hydrophobic pocket of Fbsl. We propose that Fbsl interacts with the chitobiose in unfolded N-glycoproteins, pointing the protein moiety toward E2 for ubiquitination.

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