X線結晶構造に基づくヒトFactor VIIa/Tissue Factor選択的阻害機構の解明
2006 年 48 巻 2 号 p. 147-152
詳細
2006 年 48 巻 2 号 p. 147-152
Factor VIIa/tissue factor is a key serine protease for initiation of blood coagulation. It is seen as promising target for the developing new anticoagulant drugs. X-ray crystal structures of human factor VIIa/tissue factor in complex with peptide mimetic inhibitors revealed important interactions for the selective inhibition of factor VIIa/tissue factor. These observations should provide some important information for a design of new factor VIIa selective inhibitors.
