Changes in Fluoride Concentration in Bones and Teeth of Mice Fed Commercial Diets

Abstract

Commercial diets for rats and mice contain 9-30 ppm of fluoride. It is not clear how much when fluoride accumulates in bones and teeth of mice when they eat these diets for their lifetime. We began our study with 40 mice and killed 10 mice every 6 months to determine the fluoride in them. The mean fluoride concentration in teeth of 10 mice was 115.1 ppm before the experiment and it increased to 188.6 ppm at 78 weeks after beginning the study.
In the parietal bone and femur the concentration was about 200 ppm before the experiment. Mean concentration of fluoride in parietal bone increased to 834.4 ppm at 78 weeks after beginning the study, and the mean concentration in the femur increased to 601.8 ppm.
In conclusion, fluoride contained in the diet accumulated remarkably in bones and teeth during the feeding period.