Journal of Epidemiology
Online ISSN : 1349-9092
Print ISSN : 0917-5040
Original Article
Mortality Among Japanese With a History of Kawasaki Disease: Results at the End of 2009
Yosikazu NakamuraEiko AsoMayumi YashiroSatoshi TsuboiTakao KojoYasuko AoyamaKazuhiko KotaniRitei UeharaHiroshi Yanagawa
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2013 Volume 23 Issue 6 Pages 429-434

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Abstract

Background: The long-term outcomes of Kawasaki disease (KD) are unknown.
Methods: Fifty-two collaborating hospitals collected data on all patients who had received a new definite diagnosis of KD between July 1982 and December 1992. Patients were followed until December 31, 2009 or death. Standardized mortality ratios (SMRs) were calculated based on Japanese vital statistics data.
Results: Of the 6576 patients enrolled, 46 (35 males and 11 females) died (SMR: 1.00; 95% CI: 0.73–1.34). Among persons without cardiac sequelae, SMRs were not high after the acute phase of KD (SMR: 0.65; 95% CI: 0.41–0.96). Among persons with cardiac sequelae, 13 males and 1 female died during the observation period (SMR: 1.86; 95% CI: 1.02–3.13).
Conclusions: In this cohort, the mortality rate among Japanese with cardiac sequelae due to KD was significantly higher than that of the general population. In contrast, the rates for males and females without sequelae were not elevated.

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© 2013 Yosikazu Nakamura et al. This is an open access article distributed under the terms of Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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