1995 年 5 巻 2 号 p. 87-94
The present study aimed at examining relationships between baseline lipids to 10-year mortality from all causes and cancer. Subjects comprised 1202 men and 2054 women ranging in age from 40 to 80 years living in Toda City, an urban area of Japan. They were residents who had completed multiphasic health check-ups as the baseline survey between March 1979 and February 1981. Relationships of fasting lipids at baseline to 10-year deaths were analyzed using univariate and multivariate logistic regression analysis. One hundred and seventy-two died over the 10 years. Cancer was the most common cause of death, accounting for 44 percent of deaths, followed by stroke, and congestive heart failure. Total serum cholesterol (TC) at baseline was inversely related to all-cause mortality in men, even after adjustment of body mass index, systolic blood pressure, smoking habits, and drinking habits, with odds ratio showing 0.55 in 2nd tertile and 0.74 in 3rd tertile vs 1.00 in first tertile. In women, an inverse relationship of TC to 10-year all-cause mortality did not reach significant level either in crude or adjusted odds ratios. A significant inverse relationship between baseline high density lipoprotein cholesterol (HDL-C) and all-cause mortality in adjusted odds ratios was found in men alone. Serum triglyceride (TG) and (TC-HDL-C)/TC(atherosclerotic index, Al) showed no consistent relationship to mortalities from all causes in either men or women. A relationship of TC to cancer death was insignificant in both crudeand adjusted odds ratios in men. A significantly inverse relation of HDL-C to cancer death was recognized in adjusted odds ratios in men. The relation did not substantially differ according to observation period. An inverse relation of HDL-C with cancer death in women was not significant. Relationships of TG and Al to cancer death were diverse for both sexes. The present study thus revealed the inverse relationship of TC and HDL-C to all-cause and cancer mortalities in men. J Epidemiol, 1995; 5 : 87-94.