糞便懸濁液投与法を用いた早産児マウス敗血症モデルの作成と臨床課題への応用

抄録

 Recently, a cecal slurry (CS) method was established by Wynn JL, in which a fecal suspension (CS) was prepared from contents of the appendix of adult mice and intraperitoneally administered to the subject mice. In addition, by creating and storing a large amount of CS preservation solution at once following the method reported by Starr ME, the experimental reproducibility of CS model has been improved.

 We have applied these techniques to 4-day old newborn mice and created preterm sepsis mouse model. We believe that CS model is the best solution for modeling neonatal sepsis in the condition comparing between same-age newborn pups. In this paper, the current status of our application of this model to elucidate clinical questions will be outlined.