Concentration of cephalothin in body fluids and tissue samples of          Thoroughbred horses

Taisuke KURODA; Yohei MINAMIJIMA; Hidekazu NIWA; Hiroshi MITA; Norihisa TAMURA; Kentaro FUKUDA; Atsutoshi KUWANO; Fumio SATO

doi:10.1294/jes.33.51

Note

Concentration of cephalothin in body fluids and tissue samples of Thoroughbred horses

Taisuke KURODA, Yohei MINAMIJIMA, Hidekazu NIWA, Hiroshi MITA, Norihisa TAMURA, Kentaro FUKUDA, Atsutoshi KUWANO, Fumio SATO

著者情報

Taisuke KURODA
Clinical Veterinary Medicine Division, Equine Research Institute, Japan Racing Association, Tochigi 329-0412, Japan
Yohei MINAMIJIMA
Laboratory of Racing Chemistry, Tochigi 320-0851, Japan
Hidekazu NIWA
Microbiology Division, Equine Research Institute, Japan Racing Association, Tochigi 329-0412, Japan
Hiroshi MITA
Clinical Veterinary Medicine Division, Equine Research Institute, Japan Racing Association, Tochigi 329-0412, Japan
Norihisa TAMURA
Clinical Veterinary Medicine Division, Equine Research Institute, Japan Racing Association, Tochigi 329-0412, Japan
Kentaro FUKUDA
Clinical Veterinary Medicine Division, Equine Research Institute, Japan Racing Association, Tochigi 329-0412, Japan
Atsutoshi KUWANO
Clinical Veterinary Medicine Division, Equine Research Institute, Japan Racing Association, Tochigi 329-0412, Japan
Fumio SATO
Clinical Veterinary Medicine Division, Equine Research Institute, Japan Racing Association, Tochigi 329-0412, Japan

キーワード: body fluid, cephalosporins, pharmacokinetics, tissue

ジャーナルオープンアクセス

2022 年 33 巻 3 号 p. 51-54

DOI https://doi.org/10.1294/jes.33.51

詳細

抄録

Cephalothin (CET) concentrations in body fluids (plasma, synovial fluid, pleural fluid, peritoneal fluid, and aqueous humor) and tissue samples (bone, lung, jejunum, hoof, and subcutaneous tissue) were investigated to consider the treatment of infectious diseases in horses. CET 22 mg/kg body weight was intravenously administered to 12 horses. Samples were collected from four different horses at 1, 3, and 5 hr after administration. The CET concentration in body fluids other than aqueous humor was maintained above the MIC₉₀ values of Streptococcus zooepidemicus and Staphylococcus aureus until 5 hr, but it was not maintained above that of S. aureus in bone. CET (22 mg/kg twice a day) is effective for septic arthritis, pleuritis, and peritonitis caused by gram-positive bacteria but ineffective for osteomyelitis.

責任著者(Corresponding author)

J-STAGEへの登録はこちら（無料）