Sequential Injection Spectrophotometric Method for the Assay of Paracetamol in Drug Formulations

Original Paper

Abstract

Sequential injection analysis technique was employed as a successful tool for titrimetric determination of paracetamol in drug formulation. The potential aspect of paracetamol to reduce the absorbance of potassium permanganate in sulfuric acid media was applied to develop an ideal spectrophotometric data. The super modified simplex computer program was operated to optimize the main reaction parameters such as sulfuric acid and potassium permanganate concentrations and the (3^f) factorial design was employed for studying their interaction effects. This method was found to be optimum at 1.79×10^-3 mol dm^-3 potassium permanganate and 0.071 mol dm^-3 sulfuric acid concentrations for the detection limit between 50 to 350 ppm. The results obtained showed an accurate outcome when statistically compared with the BP standard method. The method reveals no interferences from most of the added excipients in drug formulation.