The Journal of General and Applied Microbiology
Online ISSN : 1349-8037
Print ISSN : 0022-1260
ISSN-L : 0022-1260
A comparative evaluation of Cephalosporin C production using various immobilization modes
Pradeep SrivastavaSubir Kundu
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1998 Volume 44 Issue 2 Pages 113-117

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Abstract

The production of Cephalosporin C was investigated in a lab-scale 1.4 / air-lift reactor (ALR), using various immobilization modes. Bioparticles were developed by forming biofilm of growing hyphae around an inorganic siran particle which contained spores of the organism. Silk sachet was the other immobilization matrix. The maximum specific growth rate of the Cephalosporium acremonium, free cells, pellets, siran carrier and silk sachets were 0.037, 0.003, 0.047, and 0.035 h−1, and specific antibiotic productivities (as compared to 100% for free cells) were 180, 150, and 125% for siran carrier, silk sachets and pellets, respectively. Immobilization modes exhibited enhanced volumetric oxygen transfer coefficient and well-controlled, three-phase hydrodynamics.

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© 1998 by The Applied Microbiology, Molecular and Cellular Biosciences Research Foundation
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