The Journal of General and Applied Microbiology
Online ISSN : 1349-8037
Print ISSN : 0022-1260
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1-Methoxypyrrole-2-carboxamide—A new pyrrole compound isolated from Streptomyces griseocarneus SWW368
Watsapon WattanasuepsinBungonsiri IntraJirayut EuanorasetrYoshihiro WatanabeRatchanee MingmaWataru FukasawaMihoko MoriAtsuko MatsumotoKazuro ShiomiWatanalai Panbangred
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2017 Volume 63 Issue 4 Pages 207-211


A new pyrrole compound, 1-methoxypyrrole-2-carboxamide, was obtained from a culture broth of Streptomyces griseocarneus SWW368, which was isolated from the rhizospheric soil under a Para rubber tree (Hevea brasiliensis). The chemical structure was elucidated by 1D NMR, 2D NMR, and MS, as a pyrrole ring with a N-methoxy group and a primary amide group. It exhibited antibacterial properties against Kocuria rhizophila, Staphylococcus aureus and Xanthomonas campestris pv. oryzae; however, cytotoxicity of the compound at 714 μM against several mammalian tumor cell lines, i.e. A549, PANC1, HT29, HT1299 and HeLa S3, were not detected.

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© 2017, Applied Microbiology, Molecular and Cellular Biosciences Research Foundation
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