The Journal of General and Applied Microbiology
Online ISSN : 1349-8037
Print ISSN : 0022-1260
ISSN-L : 0022-1260
POLYMERIC PHENYLPROPENOIDS ARE THE ACTIVE COMPONENTS IN THE PINE CONE EXTRACT THAT INHIBIT THE REPLICATION OF TYPE-1 HUMAN IMMUNODEFICIENCY VIRUS IN VITRO
PATRICK K. LAITOSHINARI OH-HARAYUKA TAMURAYUTAKA KAWAZOEKUNIO KONNOHIROSHI SAKAGAMIAKIKO TANAKAMEIHAN NONOYAMA
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1992 Volume 38 Issue 4 Pages 303-312

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Abstract

We have previously shown that an alkaline extract from cones of pine trees could significantly inhibit HIV-1 replication in vitro. Ultraviolet, infrared, thin-layered chromatography and nuclear magnetic resonance analyses showed that polymeric phenylpropenoids might be the active ingredient in the alkaline extract that inhibited HIV-1 replication. We synthesized polymeric phenylpropenoids by dehydrogenation of caffeic acid, p-coumaric acid, ferulic acid and coniferyl alcohol. All 4 synthetic isopolymers had anti-HIV activity comparable to that found in the alkaline pine cone extract. Additionally, 3 of the 4 polymers blocked infection of cell by herpes simplex type-1 virus. Among the monomers, only caffeic acid had anti-HIV activity, but was also toxic to cells. None of the monomers had impact on herpes simplex virus infection.

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