Large rivers with high sediment discharge, such as the Amazon, Ganges-Brahmaputra, and Huanghe (Yellow) rivers, have formed mega-deltas at their mouths. This paper reviews morphology and sediments of mega-deltas and their Holocene evolution in relation to sea-level changes, channel avulsion, and past-sediment discharge. Application of various radiometric dating techniques to delta deposits, especially since the 1980's has made it possible to clarify delta evolution dynamically on 10-to 1000-year time scales. Most of the deltas are located in developing countries, and have environmental problems principally caused by human activities. For the evaluation of current status and human activities in deltas and drainage basins, both natural and anthropogenic changes of deltas should be analyzed from the viewpoints of geology, sedimentology, and their evolution.