ANTIMICROBIAL ACITIVITY OF HEPATICAE FROM HONG KONG AND BIOACTIVITY-DIRECTED ISOLATION OF ISORICCARDIN C1'-MONOMETHYL ETHER, A NEW CYCLIC BIS(BIBENZYL) DERIVATIVE

Abstract

  A total of 34 species of hepatices were collected from various sites of Hong Kong. Extracts of these species are screened for antimicrobial activity, and 28 species showed repeatable biological activity warranting further investigation. From the 95% ethanolic extract of Plagiochila sciophila Nees, guided by bioactivity-directed isolation, a new cyclic bis(bibenzyl) derivative named isoriccardin C1'-monomethyl ether (1) and the previously known diterpene dialdehyde perrottetianal A (3) were isolated.