Management of Hyperuricemia in the Occupational Health with Special Reference to Metabolic Syndrome

Abstract

In 1996, the need for the clinical guideline for the management of hyperuricemia and gout was proposed in the consensus conference held in the 29 th annual meeting of Japanese Society of Purine and Pyrimidine Metabolism (president Yuji Matsuzawa) . In the consensus conference, following announcement was made.
1. Majority of patients with hyperuricemia is under the condition of multiple risk factor clustering syndrome, thus, hyperuricemia per se should be counted for one of the typical lifestyle related disease.
2. Medical management should be directed independently for the treatment of gouty arthritis and for the control of serum uric acid level.
3. Serum uric acid level should be taken into account the possible cardiovascular risk factor.
4. Urine alkalization should be started if there is no symptom of having hyperuricemia for the prophylaxis of urinary stones and renal dysfunction.
5. All the medical management should be considered under the consensus of the many expert physicians dealing hyperuricemia and gout.
This principal announcement was made by the consensus conference and the simple management recommendation of 6-7-8 rule was proposed through the consensus of expert physicians. Recently, the guideline committee was organized in the Japanese Society of Gout and Nucleic Acid Metabolism (previous Japanese Society of Purine and Pyrimidine Metabolism) and the Guideline for the Management of Hyperuricemia and Gout was published in August 2002. In the new guideline, the above policy was succeeded and evidence was collected to give guideline the contemporary clinical usefulness and value. It will help in the proper management of hyperuricemia in the apparently healthy persons in the occupational health, having multiple risk factors and metabolic syndrome.