2016 Volume 15 Issue 1 Pages 12-20
Mangosteen (Garcinia mangostana L.) is cultivated in South-east Asia and people named as it ‘Queen of fruits.’ The mangosteen pericarp has been used as a traditional medicine for many years. We carried out repeated dietary dose toxicity study of the hot water extracts of mangosteen pericarp (Mangostin aqua) at dose of 0, 2, 4％ in SD rats to investigate the safety. No deaths occurred and there were no treatment related effects in clinical observation, body weights, food and water consumption, hematology, serum biochemistry and pathological examinations. Therefore, the NOAEL of mangosteen pericarp extract in the present study was assumed to be 4％ (3163 mg/kg/day for males and 3344 mg/kg/day for females).