Journal of Arrhythmia
Online ISSN : 1883-2148
Print ISSN : 1880-4276
Original Articles
Efficacy of Additional Amiodarone Therapy in Patients with an Implantable Cardioverter-Defibrillator
Naomichi MatsumotoKoichiro KumagaiMasahiro OgawaKunihiro MatsuoTomoo YasudaHideo TakashimaChiharu MitsutakeSoichi MuraokaAkira MatsunagaShin-ichiro MiuraKeijiro Saku
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2010 Volume 26 Issue 2 Pages 103-110

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Abstract

Introduction: We examined whether the additional use of amiodarone (AMD) under implantable cardioverter-defibrillator (ICD) therapy may have beneficial effects in patients at risk for lethal ventricular arrhythmias with structural heart diseases.
Methods: Sixty patients (47 males, mean age, 62±13 years) with structural heart disease who underwent ICD implantation were retrospectively analyzed. There were 2 groups: one group (AMD group) was treated with AMD (n=33) and the other group (non-AMD group) was treated without AMD (n=27). We compared the incidence and appropriateness of ICD shock therapy between two groups.
Results: During a mean follow-up of 28±17 months, we identified a total of 62 episodes in 18 patients (30%) who received ICD shock therapy. ICD shock episodes were significantly less frequent in AMD group than in non-AMD group (15% versus 48%, P<0.01), while inappropriate shock episodes were greater in non-AMD group than in AMD group (49% versus 4%, P=0.03). In cumulative probability of shock events, the risk of events was significantly lower in AMD group (P=0.007). Of 4 patients who died in AMD group, we observed one fatal pulmonary fibrosis.
Conclusions: Additional AMD therapy in patients with an ICD may be effective in reducing the risk of shock discharge.

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© 2010 Japanese Heart Rhythm Society
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