The QT Intervals in Infancy and Time for Infantile ECG Screening for Long QT Syndrome

Masao Yoshinaga; Yoshiaki Kato; Yuichi Nomura; Daisuke Hazeki; Toshiaki Yasuda; Kazuhiro Takahashi; Takashi Higaki; Yuji Tanaka; Akihiro Wada; Hitoshi Horigome; Hideto Takahashi; Kentaro Ueno; Hiroshi Suzuki; Masami Nagashima

doi:10.4020/jhrs.27.193

Original Articles

The QT Intervals in Infancy and Time for Infantile ECG Screening for Long QT Syndrome

Masao Yoshinaga ^†, Yoshiaki Kato ^†, Yuichi Nomura ^†, Daisuke Hazeki ^†, Toshiaki Yasuda ^†, Kazuhiro Takahashi ^†, Takashi Higaki ^†, Yuji Tanaka ^†, Akihiro Wada ^†, Hitoshi Horigome ^†, Hideto Takahashi ^†, Kentaro Ueno ^†, Hiroshi Suzuki ^†, Masami Nagashima ^†

著者情報

Masao Yoshinaga ^†
Department of Pediatrics, National Hospital Organization Kagoshima Medical Center
Yoshiaki Kato ^†
Department of Child Health, Graduate School of Comprehensive Human Sciences, University of Tsukuba
Yuichi Nomura ^†
Department of Pediatrics, Kagoshima University Graduate School of Medicine and Dental Science
Daisuke Hazeki ^†
Department of Pediatrics, National Hospital Organization Kagoshima Medical Center
Toshiaki Yasuda ^†
Department of Cardiology, Aichi Children’s Health and Medical Center
Kazuhiro Takahashi ^†
Department of Pediatric Cardiology, Okinawa Prefectural Nanbu Medical & Children’s Center
Takashi Higaki ^†
Department of Pediatrics, Ehime University Graduate School of Medicine
Yuji Tanaka ^†
Department of Pediatrics, National Hospital Organization Kagoshima Medical Center
Akihiro Wada ^†
Department of Pediatrics, National Hospital Organization Kagoshima Medical Center
Hitoshi Horigome ^†
Department of Child Health, Graduate School of Comprehensive Human Sciences, University of Tsukuba
Hideto Takahashi ^†
Department of Epidemiology, Graduate School of Comprehensive Human Sciences, University of Tsukuba
Kentaro Ueno ^†
Department of Pediatrics, Kagoshima University Graduate School of Medicine and Dental Science
Hiroshi Suzuki ^†
Division of Pediatrics, Department of Homeostatic Regulation and Developments, Niigata University School of Medicine and Dental Science
Masami Nagashima ^†
Department of Cardiology, Aichi Children’s Health and Medical Center
著者の貢献

†Masao Yoshinaga, Yoshiaki Kato, Yuichi Nomura, Daisuke Hazeki, Toshiaki Yasuda, Kazuhiro Takahashi, Takashi Higaki, Yuji Tanaka, Akihiro Wada, Hitoshi Horigome, Hideto Takahashi, Kentaro Ueno, Hiroshi Suzuki, Masami Nagashimaは本研究に等しく貢献した。

キーワード: Electrocardiography, Long QT syndrome, Death (sudden)

ジャーナルフリー

2011 年 27 巻 3 号 p. 193-201

DOI https://doi.org/10.4020/jhrs.27.193

詳細

抄録

Background: Electrocardiographic and molecular studies have clarified an association between sudden infant death syndrome (SIDS) and long QT syndrome (LQTS), and few data are available for the QT interval in infancy from birth to 1 year of age. Appropriate time of electrocardiographic screening is not clarified. Medical examinations during infancy are mandatory in Japan.
Methods and Results: The study population included 1,058 infants. Electrocardiograms were collected with information of infants at birth and at examination. The QT intervals of three consecutive beats were measured in lead V₅. Statistical analysis revealed that the following formula was appropriate to minimize the effect of heart rate for infants: corrected QT interval; QTc = QT interval/RR interval^0.43. Subjects were divided into four groups as follows: 0–2, 3–6, 6–11, and 12–52 weeks of age. Tukey’s multiple comparison showed that the QTc intervals were longest (p<0.0001) in subjects who were 6–11 weeks of age.
Conclusions: The QTc interval showed the highest peak at 6–11 weeks of age in infancy. The peak period of occurrence of SIDS is at approximately 2 months of age. An appropriate time of electrocardiographic screening for QT prolongation will be one month of age, and follow-up studies are needed.

責任著者(Corresponding author)

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