Journal of Health Science
Online ISSN : 1347-5207
Print ISSN : 1344-9702
ISSN-L : 1344-9702
RESEARCH LETTERS
The Suppressing Effect of the Extract from Cassia nomame on Clastogenicity and Cytotoxicity of Mitomycin C in CHO Cells
Shin’ichi KadowakiKazufumi NaitouYoshinori TakaharaKoji Yamamoto
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JOURNAL FREE ACCESS

2001 Volume 47 Issue 1 Pages 86-88

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Abstract

Chinese hamster ovary (CHO) K1 cells were treated with 2.5 μM Mitomycin C (MMC) for one hour and incubated in Ham’s F12 medium containing 10% fetal bovine serum or in the medium supplemented with the extract from Cassia nomame pods, leaves and stems. The frequency of cells with chromosome aberrations was significantly lowered by the extract. Proliferation of CHO cells was suppressed by a 1-hr MMC treatment, but the suppression was nullified by the presence of the extract. These findings suggest that the extract can prevent the physiological damage caused by MMC.

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© 2001 by The Pharmaceutical Society of Japan
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