Adsorption Studies of Artesunate: Evaluation of Saline Cathartics as Additive in Management of Artesunate Poisoning

Orish Ebere Orisakwe; Adeola Oluboyo; Sabinus Ofoefule; Ejeatuluchukwu Obi; Ndidi Ilondu; Onyenmechi Johnson Afonne; Patrick Agbasi; Danladi Husaini Chiroma

doi:10.1248/jhs.47.491

RESEARCH LETTERS

Adsorption Studies of Artesunate: Evaluation of Saline Cathartics as Additive in Management of Artesunate Poisoning

Orish Ebere Orisakwe, Adeola Oluboyo, Sabinus Ofoefule, Ejeatuluchukwu Obi, Ndidi Ilondu, Onyenmechi Johnson Afonne, Patrick Agbasi, Danladi Husaini Chiroma

Author information

Orish Ebere Orisakwe
Toxicology Unit, Department of Pharmacology, College of Health Sciences, Nnamdi Azikiwe University
Adeola Oluboyo
Toxicology Unit, Department of Pharmacology, College of Health Sciences, Nnamdi Azikiwe University
Sabinus Ofoefule
Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Nigeria
Ejeatuluchukwu Obi
Toxicology Unit, Department of Pharmacology, College of Health Sciences, Nnamdi Azikiwe University
Ndidi Ilondu
Toxicology Unit, Department of Pharmacology, College of Health Sciences, Nnamdi Azikiwe University
Onyenmechi Johnson Afonne
Toxicology Unit, Department of Pharmacology, College of Health Sciences, Nnamdi Azikiwe University
Patrick Agbasi
Toxicology Unit, Department of Pharmacology, College of Health Sciences, Nnamdi Azikiwe University
Danladi Husaini Chiroma
Toxicology Unit, Department of Pharmacology, College of Health Sciences, Nnamdi Azikiwe University

Keywords: saline cathartic, artesunate, activated charcoal, adsorption

JOURNAL FREE ACCESS

2001 Volume 47 Issue 5 Pages 491-494

DOI https://doi.org/10.1248/jhs.47.491

Details

Abstract

The effect of saline cathartics magnesium sulphate, sodium sulphate, and sodium citrate on adsorptive capacity of activated charcoal (AC) was investigated in vitro. Solutions of artesunate alone and artesunate with 7.5 mg/ml cathartics solution were vortex mixed for 30 sec with different quantities of AC, incubated in water bath shaker for 30 min at 37°C and analysed for free artesunate spectrophotometrically at 328 nm. Addition of the cathartics caused a significant increase (p < 0.05) in the adsorption of artesunate to activated charcoal. The descending order of increased adsorption by the cathartics is magnesium sulphate, sodium citrate and sodium sulphate.

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