Bisphenol-A Administration during Pregnancy Results in Fetal Exposure in Mice and Monkeys

Kaoru Uchida; Atsuko Suzuki; Yoshio Kobayashi; David Lee Buchanan; Tomomi Sato; Hajime Watanabe; Yoshinao Katsu; Juri Suzuki; Kazuo Asaoka; Chisato Mori; Koji Arizono; Taisen Iguchi

doi:10.1248/jhs.48.579

RESEARCH LETTERS

Bisphenol-A Administration during Pregnancy Results in Fetal Exposure in Mice and Monkeys

Kaoru Uchida, Atsuko Suzuki, Yoshio Kobayashi, David Lee Buchanan, Tomomi Sato, Hajime Watanabe, Yoshinao Katsu, Juri Suzuki, Kazuo Asaoka, Chisato Mori, Koji Arizono, Taisen Iguchi

Author information

Kaoru Uchida
Center for Integrative Bioscience, Okazaki National Research Institutes
Department of Molecular Biomechanics, The Graduate University for Advanced Studies
CREST, Japan Science and Technology Corporation
Atsuko Suzuki
Center for Integrative Bioscience, Okazaki National Research Institutes
Graduate School of Integrated Science, Yokohama City University
Yoshio Kobayashi
Technical Laboratory, Analysis Center Corporation
David Lee Buchanan
Center for Integrative Bioscience, Okazaki National Research Institutes
CREST, Japan Science and Technology Corporation
Tomomi Sato
Graduate School of Integrated Science, Yokohama City University
Hajime Watanabe
Center for Integrative Bioscience, Okazaki National Research Institutes
CREST, Japan Science and Technology Corporation
Yoshinao Katsu
Center for Integrative Bioscience, Okazaki National Research Institutes
CREST, Japan Science and Technology Corporation
Juri Suzuki
Primate Research Institute, Kyoto University
Kazuo Asaoka
Primate Research Institute, Kyoto University
Chisato Mori
CREST, Japan Science and Technology Corporation
Department of Anatomy and Cell Biology, School of Medicine, Chiba University
Koji Arizono
CREST, Japan Science and Technology Corporation
Faculty of Environmental and Symbiotic Sciences, Prefectural University of Kumamoto
Taisen Iguchi
Center for Integrative Bioscience, Okazaki National Research Institutes
Department of Molecular Biomechanics, The Graduate University for Advanced Studies
CREST, Japan Science and Technology Corporation
Graduate School of Integrated Science, Yokohama City University

Keywords: bisphenol-A, pregnancy, fetus, mouse, monkey

JOURNAL FREE ACCESS

2002 Volume 48 Issue 6 Pages 579-582

DOI https://doi.org/10.1248/jhs.48.579

Details

Abstract

Placental transfer of bisphenol-A (BPA) was studied in mice and Japanese monkeys (Macaca fuscata). BPA was found in maternal and fetal sera, liver, brain, uteri, testes and placenta as early as 30 min after a single subcutaneous (s.c.) injection to 17 days of pregnancy in mice. BPA was also found in fetal liver, kidney, and brain of Japanese monkeys 1 hr after a single s.c. injection to 150 days of pregnancy. These results clearly indicate that the maternal placental barrier can not protect the fetus from the consequences of BPA exposure in these species.

Corresponding author

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