2004 Volume 50 Issue 2 Pages 164-168
A biological specimen, urine, was prepared by the most simple sample preparation method, direct dilution, and determination of seven elements in the urine samples, Fe, Cu, Zn, Se, As, Cd, and Pb, was investigated by inductively coupled plasma mass spectrometry (ICP-MS). In addition, acid-decomposed samples were similarly investigated. Regarding the matrix effect of concomitant components, as the sodium hydrochloride concentration increased, the observed ion intensity of the measured element linearly decreased. Matrix interference by sodium hydrochloride could be fairly corrected by addition of internal standard elements excluding determination of Fe and Zn. On comparison of the measured values of samples prepared by direct dilution and acid-decomposition samples, the values were slightly lower in the samples prepared by direct dilution for many elements. For Zn and As, the analytical results of the human urine standard reference material were well consistent with the certified values.
