Journal of Health Science
Online ISSN : 1347-5207
Print ISSN : 1344-9702
ISSN-L : 1344-9702
RESEARCH LETTERS
Protective Effect of (-)-Epigallocatechin Gallate on Acute Experimental Colitis
Miyako MochizukiNoboru Hasegawa
著者情報
ジャーナル フリー

2005 年 51 巻 3 号 p. 362-364

詳細
抄録

We studied the ameliorative effect of (-)-epigallocatechin gallate (EGCG) on inflammatory bowel disease (IBD) induced by ethanolic 2,4,6-trinitrobenzene sulfonic acid (TNBS) in male 7-week-old rats. Intestinal lesions were associated with macroscopic damage score and measured as increase in myeloperoxidase (MPO) activity in mucosa. Pretreatment with EGCG (30 mg/kg daily i.g. for 10 days) significantly reduced macroscopic damage score, inhibited MPO activity and enhanced superoxide dismutase activity. These observations confirmed that EGCG can ameliorate acute experimental colitis by suppression of superoxide generation from colonic tissue.

著者関連情報
© 2005 by The Pharmaceutical Society of Japan
前の記事 次の記事
feedback
Top