Proportion of Murine Cytotoxic T Cells is Increased by High Molecular-Weight Fucoidan Extracted from Okinawa mozuku (Cladosiphon okamuranus)

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Male BALB/c mice were administered three fucoidans with different molecular weights prepared from Okinawa mozuku (Cladosiphon okamuranus). The proportion of CD8⁺ cells in the spleens of mice fed with high molecular-weight fucoidan significantly increased compared with those in mice fed a control diet. In addition, the CD4⁺/CD8⁺ ratio tended to decrease and the proportion of CD11b⁺ cells to increase. These results suggest that high molecular-weight fucoidan promotes an increase in the proportion of murine cytotoxic T cells.