Journal of Health Science
Online ISSN : 1347-5207
Print ISSN : 1344-9702
ISSN-L : 1344-9702
RAPID COMMUNICATIONS
Proportion of Murine Cytotoxic T Cells is Increased by High Molecular-Weight Fucoidan Extracted from Okinawa mozuku (Cladosiphon okamuranus)
Jun ShimizuUrara Wada-FunadaHiroshi ManoYoshiharu MatahiraMitsuaki KawaguchiMasahiro Wada
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2005 年 51 巻 3 号 p. 394-397

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Male BALB/c mice were administered three fucoidans with different molecular weights prepared from Okinawa mozuku (Cladosiphon okamuranus). The proportion of CD8+ cells in the spleens of mice fed with high molecular-weight fucoidan significantly increased compared with those in mice fed a control diet. In addition, the CD4+/CD8+ ratio tended to decrease and the proportion of CD11b+ cells to increase. These results suggest that high molecular-weight fucoidan promotes an increase in the proportion of murine cytotoxic T cells.

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© 2005 by The Pharmaceutical Society of Japan
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