Serum Caeruloplasmin as a Coronary Risk Factor in Patients with Acute Myocardial Infarction with Normal Lipid Profile

Abstract

There have been studies demonstrating that serum caeruloplasmin acts as an antioxidant in cardiovascular disease. However, several studies have demonstrated that it acts as an independent risk factor in patients with cardiovascular disease. To ascertain the role of caeruloplasmin in normolipidemic acute myocardial infarction patients, we investigated the correlation between the serum caeruloplasmin level and incidence of cardiovascular disease in individuals with normal lipid profiles. The levels of caeruloplasmin were significantly higher in patient sera than in those of controls (p<0.001) and the difference in the lipid profiles was also significant (p<0.001). These results suggest that caeruloplasmin may act as a prooxidant and appears to be a risk factor in this disease.