Journal of Health Science
Online ISSN : 1347-5207
Print ISSN : 1344-9702
RESEARCH LETTERS
Inhibitory Effect of Relaxin-3 on Insulin Secretion in Isolated Pancreas and Insulinoma
Hiroyuki YamamotoTakeo AraiRyota TasakaYasunori MoriKazuaki IguchiKeiko UnnoMinoru Hoshino
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Volume 55 (2009) Issue 1 Pages 132-137

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Abstract

Relaxin-3 is a recently discovered member of the insulin superfamily and is a ligand for three orphan G-protein-coupled receptors: GPCR135, GPCR142 and LGR7 (leucine-rich repeat-containing G-protein-coupled receptor 7). GPCR135 mRNA is expressed in the pancreas, however, it is not known, whether the peptide affects pancreatic islet function. Reverse transcriptase (RT)-PCR and radioreceptor assay have shown that the relaxin-3 receptor (GPCR135) is expressed in pancreatic islets and rat insulinoma, but LGR7 is not expressed. Moreover, relaxin-3 has been revealed to inhibit the secretion of insulin from pancreatic islets. However, we can not detect relaxin-3 in small intestine and pancreas. These results suggest a novel role of relaxin-3 in the regulation of insulin release.

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© 2009 by The Pharmaceutical Society of Japan
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