Journal of Health Science
Online ISSN : 1347-5207
Print ISSN : 1344-9702
ISSN-L : 1344-9702
RAPID COMMUNICATIONS
Nuclear Factor κB Inhibition by Dibenzoylmethane Derivatives
Nobuyasu MatsuuraRika MurakamiTomoyuki KatayamaSatoshi HibinoTominari ChoshiMasashi Yamada
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2009 年 55 巻 2 号 p. 311-313

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We established stable HeLa transformants with reporter genes containing nuclear factor (NF)-κB response elements to measure NF-κB inhibition. Tumor necrosis factor (TNF)-α treatment induced a 6-fold activation of NF-κB in HeLaNF-κB-3 cells. Three chloro-derivatives of fourteen dibenzoylmethane derivatives inhibited NF-κB activity.

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© 2009 by The Pharmaceutical Society of Japan
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