衛生化学
Print ISSN : 0013-273X
マウス臓器中のメタロチオネイン濃度に対する化合物の影響(第1報)有機溶媒及び脂肪酸による肝臓メタロチオネインの増加
小野坂 敏見越智 洋子閔 庚善藤田 由紀田中 慶一
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34 巻 (1988) 5 号 p. 440-445

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Mice were injected with organic solvents and fatty acids, and the concentration of metallothionein in the mouse tissues was determined. The following results were obtained. 1. The metallothionein concentration in the liver increased by the injections of n-heptane, n-hexane and benzene. 2. The Zn-thionein concentration increased to 323±44 μg/g after the injection of n-heptane injection, and the acute cadmium toxicity was prevented by pre-injection of n-heptane. 3. The concentration of metallothionein in the mouse liver increased by the injections of oleic acid and linoleic acid. These results demonstrate that the concentration of metallothionein in the mouse liver increased by the organic solvents and fatty acids.

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