1991 年 37 巻 6 号 p. 507-511
Comparison of pharmacological activity of two cannabis extracts from cannabidiolic acid (CBDA) and tetrahydrocannabinolic acid (THCA) strains in mice was evaluated using catalepsy, hypothermia, prolongation of pentobarbital (PB)-induced sleep and locomotor activity as indices. ED50s of catalepsy of CBDA strain extract (CBDA-E) and THCA strain extract (THCA-E) were 41.0 and 20.1 mg/kg, i. v., respectively. The most effective cannabis extract inducing hypothermia was CBDA-E at a dose of 50mg/kg, i. v.. By treatments (25mg/kg, i. v.) with CBDA- and THCA-Es, PB-induced sleeping time was prolonged 4.1 and 1.8 fold, as compared with that of 1% Tween 80-saline control. In its effect on locomotive activity CBDA-E showed a tendency to decrease and THCA-E at a low dose (5 and 25mg/kg) a tendency to increase, and at a high dose (50mg/kg) to decrease horizontal activity. CBDA- and THCA-Es tested, except for a dose of 5mg/kg, significantly decreased vertical motor activity of mice. From these results, CBDA-E containing CBDA as a major component and THCA-E containing THCA as a major component were found to have different pharmacological activity.
