The effects of soluble sodium alginate of average molecular weight (A.M.W.), 1×104 (AG-1), 5×104 (AG-5) or 1×105 (AG-10) on the excretion of 3H-labeled cholesterol, Trp-P-1 and aflatoxin B1 in rat were compared with those of commercially available sodium alginate (A.M.W. : 2.7×106, AG-270) and polydextrose. In rats administered 3H-cholesterol, the simultaneous administration of AG-10 or AG-270 (100mg/kg) significantly increased the amount of isotope excreted in feces. The administration of AG-5 or AG-10 (1000 mg/kg) after the administration of the tested compounds increased the amounts isotope excretion into feces, and decreased significantly those into urine. The administration of AG-1, however, showed no effect. These results indicate that AG-5 and AG-10 exhibited the same accelerating effects on the excretion of the tested compounds as AG-270.