Study of Possible Pharmacological Actions of Aloe arborescens MILLER on Mouse, Hamster and Human Skin

抄録

Aloenin is a major constituent of Aloe arborescens MILLER which has been utilized in Japan as a folk remedy for burns, insect bites, and skin reaction. In the present study, the effects of aloenin on sebaceous gland size, hair growth and damaged skin were investigated. Aloenin significantly promoted hair growth in depilated mice, but did not affect sebaceous gland function in the hamster ear. Aloenin also had recuperative effects on tape-stripped human skin as determined from parameters such as the shape factor of corneocytes, thick abrasion, nuclear ghosts and cellular arrangement of corneocytes. Since aloenin is effective in healing damaged skin, it may be useful for the treatment of dermatological conditions in the future.