Evaluation of Oral Mucosa Irritation produced by Ozone Gel

Abstract

Ozone is a potent oxidative gas and its bactericidal effect is exploited in dental practice. However, the half-life of ozone is extremely short, which limits its ability to exert bactericidal effects on cells. Therefore, we focused on ozone gel, which is composed of a glycerin solution containing ozone, a recently developed technology, in vivo. In the course of our study, we evaluated the safety of ozone gel application to the skin and eye, as well as its effects on hemostasis and antimicrobial effects. In this study, we found that ozone gel was nontoxic to the oral mucosa. Our results suggest that ozone gel represents a clinically agent for periodontal diseases and peri-implant diseases.