Journal of Hard Tissue Biology
Online ISSN : 1880-828X
Print ISSN : 1341-7649
ISSN-L : 1341-7649
Original
Evaluation of the Osteointegration of a Novel Alkali-Treated Implant System In Vivo
Tetsuji KusumotoDerong YinHonghao ZhangLuyuan ChenHiroshi NishizakiYutaka KomasaJoji OkazakiSatoshi Komasa
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2017 年 26 巻 4 号 p. 355-360

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Previous in vitro studies of alkali-treated titanium have shown that titanium with nanonetwork structures (TNS) implants have good osteogenic induction ability and superior surface properties. Here, we aimed to develop an implanting system with superior biological properties on the basis of previous in vitro experiments, determine the biological properties of TNS implants in animal experiments, and provide a basis for future clinical use of TNS implants by dentists. In this experiment, titanium discs and screws were soaked with alkali treatment and then analyzed by scanning electron microscopy, X-ray photoelectron spectrometry, scanning probe microscopy, and other methods. Additionally, a rat femoral implant model was established, and specimens were removed at 4 and 8 weeks after implantation and analyzed by micro-computed tomography (CT). After three-dimensional reconstruction of CT images, the bone volume fraction, trabecular number, trabecular separation, and trabecular thickness were analyzed. The experimental results showed that the surfaces of implants after alkali treatment exhibited a uniform three-dimensional nanonetwork structure, indicating that preparation of the TNS implant was successful. In general, TNS implants showed stronger osseointegration than pure titanium implants and were more suitable for oral clinical applications. Thus, these TNS implants may have applications as an implantation material for in clinical dentistry and orthopedics.

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© 2017 by The Hard Tissue Biology Network Association(JHTBNet)
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