抄録
The therapeutic effects on massive dose administration of Lysozyme to 21 children with chronic sinusitis were observed through the changes of X-ray findings before and after the administration. Materials were 15 boys and 6 girls with 6.8 years of mean age. The clinico-pathological type of 21 chronic sinusitis was classified into 6 local infection types, 8 diffuse catarrhal types and 7 edematous polyp types. The state of the middle nasal meatus was open in 14 cases and closed in 7 cases. A day's dose of Lysozyme, the mean administration period and the mean of the total administration dose was 150 mg three times a day, 77 days and 7207.1mg respectively. Results were distributed in marked effective: 6 cases 28.8%, effective: 8 cases 38.1%, not effective: 7 cases 33.3% and no exacerbation case. Therefore the rate of effectiveness calculated in 66.6%. The therapeutic results did not relate to the length of administration periods and the quantity of total administration dose, but the clinicopathological type of sinusitis. Clinical symptoms and X-ray findings were improved in the most cases of local infection type and diffuse catarrhal type of sinusitis with the open middle nasal meatus, however were not improved in a part of diffuse catarrhal type and in the most cases of edematous polyp type of sinusitis with the closed middle nasal meatus.
Although the massive dose administration of Lysozyme to children chronic sinusitisis considered to be effective, it is a weak point that its effectiveness is limited to the two clinico-pathological types of sinusitis. And so, before performing this therapy, it is necessary to select materials (clinico-pathological type of sinusitis) and to avoid an aimless longterm administration.
