By repeating anoxia on a guinea pig, pathologic intravascular red cell aggregation (sludge phenomena) being accompanied with lowering of blood flow velocity resulted in the radiating cochlea arteriole that could not be recovered by only oxygen supply. By an intraperitoneal injection of adenosine triphosphate (ATP) in this model, the recovery conditions of the radiating arteriolar blood flow were continuously observed by microscope and recorded on 16mm color film. The velocity of the blood flow was measured by the recorded 16mm color film, and the heart rate was obtained from the recorded electrocardiogram. The results are as follows: When pathologic intravascular red cell aggregation was observed in the radiating arteriole, the velocity of the blood flow was 120μm/sec, calculated blood volume: 0.3×10-3mm3/min and heart rate: 82/min. Ten minutes after ATP injection, these rates increased up to 600% (720μm/sec), 633% (1.9×10-3mm3/min) and 113% (93/min) respectively, and also these recovery rates were 90%, 90% and 78% respectively, showing a remarkable improvement. As a results, ATP should be considered to be effective on the improvement of velocity of the blood flow and blood volume of radiating arteriole in the cochlea. Pharmacological mechanism of ATP concerning with the improvement of blood flow velocity of radiating arteriole in the cochlea was discussed in this article.
