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Nippon Jibiinkoka Gakkai Kaiho
Vol. 106 (2003) No. 3 P 192-198



In the 22 years between March 1979 and February 2001, we treated 16 patients 10 men and 6 women aged 10-80 years (mean: 44 years) - with mucoepidermoid carcinoma (MEC) of the salivary gland, evaluating them clinically and histopathologically. Tumor sites included 12 at the parotid gland, 3 at the submandibular gland, and 1 at the minor salivary gland. All tumors were graded histopathologically based on the criteria of Goode et al. as follows : low grade (n=10), intermediate grade (n=1), and high grade (n=5). Female gender was associated with low grade MEC and male gender with high grade MEC (P<0.05). The age at onset in high grade MEC was older than that in low grade MEC (P<0.005). Lymph-node metastasis was detected in 7 out of the 16 patients (44%) associated significantly with high grade MEC (P<0.05). Distant metastasis was detected in 4 of 16 patients (25%). Distant metastasis was significantly associated with high grade MEC (P<0.05). Local recurrence was detected in 3 of 15 patients undergoing surgery (20%). No difference was seen in local recurrence frequency between low and high grade MEC. Survival was calculated with Kaplan-Meier's method. In all 16, 5-year survival was 86% and 10-year survival 75%. Five-year survival in low grade MEC was 100%, whereas that in high grade MEC was 67% (P<0.05). In MEC of the salivary gland, it was suggested that the histopathological MEC grade evaluated by Goode's criteria significantly correlated with gender, age, lymph-node metastasis. distant metastasis, and 5-year survival.

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