単純ヘルペスウイルスによる家兎扁桃炎の実験的研究

抄録

The histo-pathological studies were made on the rabbit-tonsils inoculated with the strain SK 5 of herpes simplex virus. The results were as follows.
1) Microscopic examination of the palatine tonsil for each areas showed degenerative necrosis with polymorphonuclear leucocytes, ballonierende degeneration of the crypt epithelial cells, partial desquamation of the crypt epithelial layer, swelled endothelial cells and disappearance of lymphcytes in the lymph follicles. Tthese changes were appeared already within 12 hours after inoculation and became marked withen 72 hours, however, these changes returned nearly to the normaly after 7 days. The inclusion bodies were found as " Lipschiitz Type " in the crypt epithelial cells after 72 hours.
2) After intratonsillar inoculation, the rabbits were killed on the 1st, 3rd, 5th and 7th day and the infected tonsils emulsion were inoculated intracerebrally in the mice. They died apparently from encephalitis and their brain were found cell infiltration of the meninges, hypertrophy of the endothelium, degeneration or necrosis of nerve cells, neuroglial proliferation and perivascular cell day infiltration microscopically. The mice were injected, however, with the tonsil emulsion of the 7th after inoculation showed no signs of encephalitis and healthily survived for a long time.
3) From the results above mentioned experiments it is clear that the tonsils of the rabbits also have the sensitivity equally to the mucous membrane of the mouth against the herpes simplex virus and the tonsillitis studied histopathologically are surely viral inflamation.