As a result of some comparative basic investigations between the so called long acting sulfa drugs such as sulfisomezole, sulfamethoxypyridazine, sulfaphenazol, and sulfadimethoxine and the short acting one such as sulfisomidine, the authors found the fact that the formers had much more excellent characteristics than the latter.
These excellent characteristics, namely, were their maintenance of high concentration in blood and tissue due to the very slow urinary excretion and the low acetylation rate.
From these data, when the authors payed attention to the therapy of chronic sinusitis hitherto using with sulfa drugs, it seemed to be expected that the long acting sulfa drugs could improve the effect of therapy in chronic sinusitis.
However, as to excellent characteristics, there was little to choose among them, while each of them had the excellent characteristics itself respectively.
On the other hand, concluding from investigations in vitro, although staphylococci were a little more sensible to the long acting sulfa drugs than the previous short acting ones, they were easily to get the resistance against the formers comparatively in early stage and the degree of resistance did not diminish in a long period of time. So, in these points, it was to be considerable that these long acting sulfa drugs have not been improved.
