血流変化の蝸牛電位,及び,蝸牛神経活動電位に及ぼす影響に関する実験的研究

抄録

For a clear understanding of physiological mechanism involved in cochlear function, blood supply to inner ear, blood pressure, relationship between inner ear function and vegetative nervous system, and between physical and biological mechanism. Should be corefully studied.
By means of vestibulo-tympanal recording after Tasaki in guinea pigs and round window recording in cats, microphonics and action potentials were measured and at the same time in some animals blood pressure, blood viscosity and the velocity of the blood flow using Rein's "Thermostromuhr" in the carotid artery and the vertebral artery, was also measured.
Then following results were obtained:
1) The blood presuere has no influence on the generation of CM and AP, as far as is no there influence to the vital phenomenon, of the animale.
2) Energies which were required on generation of CM in the inner ear, were obviously supplied by blood flow, but their stocks were very little. Cochlear circulation under physiological conditions, was supplied with great surplus.
3) Ap disappeared when CM decreased down to 50% of original CM magnitude.
4) The generating mechanism of CM₁ was clearly based on biological mechamism, but of CM₂ was not decided whether on biological or on physical mechanism. But CM₂ was thought to be more like physical.
5) On CM₂ for clicks, the responce disappeared after loud sound stimulation (4000c.p.s. 95db) and then gradually recovered under asphyxia in the same mrnner as on CM₁.
6) The origin of the half wave rectification that was observed frequently near the CM₂ level, was not traced.
7) The blood flow in the stria vascularis were related directly to the cochlear function. Then the observation of the behavior of the blood flow is necessary to know the cochlear function. And the author investigated the changes of the strial blood flow corresponding to the changes of the electrical phenomenon on the cochlea, and it was felt keenly that DC and SP should be measured at the same time.
8) The increase of blood viscosity had no influence on CM and AP.
9) Except the changes in conductive efficiency in the middle ear or the intense change of the blood circulation, the vegetal nervous siistem had no direct influences on the cochlear function.
10) The change of body temperature from 37°C down to 27°C seems unrelated to cochlear function.