中耳腔の異物反応の実験的研究

Gelfoam, Spongel 等の吸収実験

抄録

Absorption of Gelfoam and Spongel, inserted in to the tympanic cavity were discussed in tympanoplasty.
This study was undertaken to investigate its relationship with the pneumatisations theory.
As experimental animals, pigs and rabbits were used, because the tympanic cavity and mastoidcells of the pigs are well-developed similar to human mastoidcells and the middle ear of the rabbit is constructed as simple antrum, which is called a bulla similar to the under-developed pneumatic cavity.
Gelfoam and Spongel were inserted in these cavityies and from ten to fourty days later histological observations were done postoperatively. In the mastoidcells and tympanic cavities of the pigs no remains of Gelfoam were seen, but histologically the homogenous or fibrous gelatin materials stained by eosin were found and inflammatory reaction of the mastoidcells was remarkable. In the cavities of the mastoidcells the small round cells, histiocytes, plasma cells, leucocytes and flat epithel cells were revealed, in which phagocytic functions was noted. The mucous membrane was thickened and oedematous. The small round cells and histiocytes were extensively infiltrated. The tympanic cavity showed a similar reaction with mastoidcells, except a fibrous proliferation of its mucous membrane. In the middle ear of the pigs, the remains of the Spongel were found from ten days to twenty days after the operation. But after the fourty days, no Spongel was found, but the mucous menbrane was oedematously thickened. In the bulla of the rabbit, the Spongel was seen after fourty days and the reaction of the bulla membrane was slight.
As control these materials were inserted in to the mucous membrane and skeletal muscles of the rabbits and histologically observed.
From this experiment, it was concluded that the Spongel tanpon inserted in the well-developed middle ear might be easily absorbable but in under-developed state absorption was very slight.