コカインのモルモツト口蓋刺激に由来するシヨツクとその予防

抄録

Following surgical manipulation of the pharyngeal area, as in tonsillectomy, and especially after local anesthesia of this area, a developement of a shock condition is frequently encountered.
A series of studies on the autonomic nervous system in the cervical and facial region have lately been carried out in our department.
Guinea pigs were used as experimental animals in the author's investigation.Cocaine was selected for this investigation.Author's experiments were divided into four groups.
In the first group of experiments, a certain amount of cocaine was injected into the palate.All of them died from shock.In the next group, a same amount of cocaine was injected subcutaneously.On the contrary none of them died.
When a same amount of cocaine was injected intravenously in the third group, only 35% of them died.
In the last group, animals were administered with chlorpromazine prior the injection of cocaine into the palate.No death occured in the last group.
Histological findings of the lung, the liver, the kidney and the adrenal in the only first group showed the changes described as " Syndrome d'irritation" by Reilly.
Shock syndrome resulted from palatine stimulation by cocaine is thought to be Reiley's phenomenon, not due to the excessive absorption of cocaine into the blood flow.