Radioallergosorbent Test(RAST)によるスギ花粉症の検討(II)スギ花粉症におけるRASTの診断的意義

抄録

The diagnosis of pollinosis is in general made on the basis of detailed clinical histories, nasal smear, skin tests, the dilution threshold of the skin, provocation tests, P-K tests, the quantity of serum total IgE concentrations and so on. Since the circulating allergen specfic IgE antibody could be measured by the radioallergosorbent test (RAST), the elevation of allergen specific IgE antibody in serum has been considered to be one of the important diagnostic evidences in the reagin (IgE)mediated allergic diseases.
The cedar specific IgE antibody was measured by RAST from 86 cases of Japanese cedar pollinosis (with positive histories, positive nasal smear, positive skin test and positive provocation test) and 8 cases of suspicious Japanese cedar pollinosis (with positive histories, positive nasal smear, positive skin test and negative provocation test). The significance of RAST on diagnosis of Japanese cedar pollinosis was evaluated by comparing RAST results with in vivo results (skin tests, the dilution threshold of the skin and provocation tests), total IgE levels and blood eosinophil counts.
Results are as follows:
1. The results of skin tests agreed with the RAST results in 76.5%. The correlation between provocation tests and RAST was 80.2%. These experimental results mean that the circulating cedar specific IgE antibody is increased in 70 to 80% of patients with cedar pollinosis diagnosed in vivo diagnostic criteria. The rise of serum cedar specific IgE antibody is regarded as an important evidence of diagnosis of Japanese cedar pollinosis.
2. There is a close relationship between the dilution threshold of the skin and the cedar specific IgE antibody levels (r=0.845).
3. The total IgE concentrations of serum did not correlate to the serum cedar specific IgE antibody levels.
4. The blood eosinophil counts had no relation to either total IgE levels or the cedar specific IgE antibody concentrations.