RadioallergosorbentTest(RAST)によるスギ花粉症の検討.III.スギ花粉症における血清IgEおよびIgE抗体の季節変動

抄録

In order to investigate the seasonal variations of serum reaginic activities in Japanese cedar pollinosis, serum IgE concentrations by the radioimmunosorbent test and cedar specific IgE antibody levels of eighteen cedar allergic patients were measured monthly by the radioallergosorbent test(March, April. May, June and July, 1973). As the number of atmospheric cedar pollen grains increased, serum IgE began to elevate and continued to raise during the cedar pollination season.It reached the maximum concentrations about two months after the end of the pollination season, then it decreased gradually and became minimum just before the next pollination season. The ratio of the maximum IgE concentration to the minimum was 3.25 fold in the mean of total 18 cases. Concerning variation patterns of serum IgE ten cases showed a monophasic pattern, eight cases a two-phasic.
Along the beginning of the cedar pollination season serum cedar specific IgE antibody levels set in acending and lasted during the season.
It attained to the peak levels at the end of the season or about a month after the season.After the peak elevations it discended gradually and dropped to the lowest levels just before the next pollination season. The ratio of the peak value of IgE antibodies to the lowest was 1.9 fold in the mean of total 18 cases. In regard to variation patients 13 cases revealed a monophasic pattern, 5 cases a two-phasic.
The seasonal changes of serum IgE concentrations and serum cedar specific IgE antibody levels are considered to depend on the fluctuations of the airborne cedar pollens (antigenic stimuli)