Partitioning of egg-white lysozyme between the serum and paranasal tissue was investigated using the ELISA method.
1) Egg-white lysozyme was detected in the paranasal tissues of 7 of 8 subjects given exogenous lysozyme reached a peak concentration in the serum in 60 minutes, whereas, 90 minutes was required to reach peak concentrations in the paranasal tissues.
2) Antibodies against egg-white lysozyme were detected in the serum of 4 of 5 subjects given exogenous lysozyme.
3) Differences in serum concentrations of lysozyme between subjects given exogenous lysozyme and subjects non-receiving lysozyme were not significant.
However, lysozyme concentrations in the paranasal tissues of all subjects receiving exogenous lysozyme were higher than in subjects not receiving an exogenous source of the enzyme.