A case of T cell origined malignant lymphoma with Mikulicz's syndrome was reported. The patient, 56 years old male, visited our clinic on May 21, 1982, complaining of synmetrical and asymptomatic swelling of the lacrimal, parotid and submandibullar glands. In physical findings, he had impairment of saliva secretion and keratoconjunctivitis sicca. The laboratory data showed hypercalcemia, hypergammaglobulinemia, high serum LDH and high serum amylase levels. And the lacrimal, parotid and submandibullar glands showed high uptake of the isotope in 67Ga scintigraphy. The parotid and submaxillary sialograms demonstrate the irregular extravasation of contrast material into the glands. The ducts are delated and stretched.
The histological findings of the parotid gland obtained by open biopsy proved the diffuse and mixed typed of malignant lymphoma. The tumor cells diffusely infiltrated into the grandullar tissue, and the structure of the glands was widely destroyed. These histological findings were simillar to those of the so-called Mikulicz's disease, which has morphologically been characterized by infiltration of abundant lymphocytes in glandullar tissue. The infiltrested lymphocytes of the case reported, however, were mostly malignant. In addition, the surface markers of the lymphocytes revealed T cell origin, and ATL antigen was positive.
