日本耳鼻咽喉科学会会報
Online ISSN : 1883-0854
Print ISSN : 0030-6622
ISSN-L : 0030-6622
放射線照射による鼻粘膜上皮の形態学的変化に関する電子顕微鏡的研究
池岡 博之大橋 淑宏丸岡 健一古下 博之中井 義明小野山 靖人
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1985 年 88 巻 11 号 p. 1562-1566

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In order to examine the effects of irradiation on the nasal epithelium, rabbits received 200kV hard X-ray irradiation at 3, 000 rad to their nasal septum. The nasal mucosa after the irradiation was examined with scanning and transmission electron microscopy in a time-course manner.
Immediately after the irradiation, few morphological changes were observed on the nasal epithelium with scanning electron microscopy, while transmission electron microscopy disclosed some morphological changes such as vacuolation and ballooning of epithelial cells, and enlargement of intercellular space. 2 weeks after the irradiation, sporadically affected changes were observed. The affected signs of the epithelial cells were observed at the wider area according to the course of time after the irradiation. 4 weeks after the irradiation, stratified arrangement of non-ciliated cells or undifferentiated cells were noted in an extensive area of the nasal mucosa 8 weeks after the irradiation, the nasal epithelium were chiefly consisted of undifferentiated cells.
Accordingly, the following conclusions were derived from the present investigation;
1) Irradiation affected the nasal ciliary epithelium.
2) The damage of the nasal epithelium by irradiation was not recovered easily.

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