The objective of the present study was to clarify the efficacy of proton pump inhibitor (PPI) therapy with esomeprazole on symptoms, signs, sleep disturbance and work productivity associated with laryngopharyngeal reflux disease (LPRD). Twenty one patients with LPRD were enrolled in present study and received esomeprazole 20 mg daily for two months. These patients with LPRD were investigated by comparing the frequency scale of gastroesohageal reflux disease (GERD), the laryngopharyngeal reflux symptom score, the objective laryngopharyngeal reflux finding score, the Pittsburg sleep quality index questionnaire and the work productivity and activity impairment questionnaire before and after treatment. We found that the scores of these parameters after treatment were significantly lower than those before treatment.
These findings indicate that LPRD might have an influence on the quality of life of affected patients including sleep disturbance and work productivity. PPI treatment might improve the symptoms and signs of LPRD also reduce the sleep disturbance and restores the work productivity of patients with LPRD. Taken together, esomeprazole was shown to be useful for the treatment of patients with LPRD.
