鼻副鼻腔癌の基礎と臨床

抄録

Sinonasal squamous cell carcinoma (SCC) is a rare tumor arising either de novo or in association with inverted papillomas (IPs). IPs are rare benign tumors of the sinonasal tract with high recurrence rates and potential for malignant transformation, although the specific mechanisms underlying the association of SCC with IP and the clinical features of SCC associated with IP versus those of de novo SCC remain unclear, with substantial debate continuing on these issues.

Human papilloma virus (HPV) has attracted much attention as a cause of sinonasal SCC. HPV-related multiphenotypic sinonasal carcinoma (HMSC) is also a sinonasal tract tumor with features of both surface-derived and salivary gland carcinoma, such as adenoid cystic carcinoma, and has been newly classified as an HPV-positive sinonasal carcinoma. A deeper understanding of the overall incidence and clinicopathological profile is required for the management of patients with HPV-related sinonasal carcinoma.

In the current review, we discuss and compare the oncological features and prognosis of patients with sinonasal SCCs based on their etiology. We also review the roles of high-risk human papilloma viruses (HPVs) in the pathogenesis of SCCs associated with IPs.